Showing posts with label weaponized. Show all posts
Showing posts with label weaponized. Show all posts

Saturday, March 9, 2013

MODERNITY as just one vast marketing ploy

At its very base base, Modernity consists of convincing other people (call 'em customers or colonies, tis the same) that you are smart (progressive/a professional scientist) and they are stupid (backward/laypeople).

Modernity and Imperialism after all grew up together and declined together: post-modernity and de-colonization being pretty much one and the same thing.

The 1920s trend to replace mom's homemade bread with  industrialized white bread and Britain's attempt to create imperialized/militarized penicillin  during WWII are two shades of the same big lie.

In most rural Nova Scotia farmhouses until recently, the biggest and cosiest room in the house was the kitchen where the big wood stove was the entire house's only form of heat.

There the kids would gather after school - by necessity in winter - to keep warm and watch mom prepare and then cook biscuits ,made from flour and water, that the kids immediately consumed. Artificial chemical preservatives need hardly enter such an immediate process.

But starting in the 1920s, bread manufacturers and their clever Goebbels of Madison Avenue successfully convince a new generation of Moms - and kids - that  mom's homemade bread was unsafe and unhygenic.

Scientists in white gowns in white factories could  put the right sort of chemicals in bread to kill all germs - and not so incidentially  - allow factory bread to be shipped a thousand miles across a nation, sit about for weeks and still not grow mold before being consumed.

Germs were destroyed - as were local bakeries.

Re-casting Mom as a lesser breed


All the moms in the Nova Scotia rural hinterland became an internal colony, as she no longer baked bread to compete with Ben's , the huge breadmaker in the imperial metropolitan centre of Halifax.

Instead she focused on cutting fish at the local fishplant and with her earnings now bought Ben's fluffy white stuff.

When I was a kid, the local children were embarrassed to have to bring delicious homemade bread and baked-beans sandwiches to school and would trade it for sandwiches of Ben's bread and Kraft sandwich spread.

Howard Florey was the son of an industrialist and knew all there was to know about how modernity cum industrialization cum imperialism worked.

 He was always most reluctant to ever give anyone some of his penicillium spores (usually sending rubbishy mutant spores unlikely to produce penicillin, if he was pushed to respond conventionally as one scientist to another scientist's request for some of the material mentioned in his published article.)

By contrast, he was almost willing to be seen forcing some of his Oxford Standard dried penicillin powder upon you , so as to prove he had made dry penicillin first and had set down the standard for others to follow.

He was actually doing nothing that Britain's political and industrial elite hadn't already worked out for themselves long before.

Give a colonist a vial of British-made penicillin and he could save a life for a day but then he'd need to trade cheap Indian cotton for expensive British  penicillin, forever, if he hoped to go on saving Indian lives.

"Give a man a fish" et al, in a new guise.

Enter Pulvertaft, Atkinson and Duhig 


By contrast, Robert Pulvertaft and Nancy Atkinson had different plans.

Howard Florey visited both and publicly - reluctantly - praised both, but was really was privately furious at both.

Pulvertaft in Cairo, Egypt had used Florey-made and British industry-made dry penicillin powder but they often arrived in pretty bad shape - unlike a fungi spore they didn't really survive travel well.

 But Pulvertaft had also secretly got a sample of Fleming's penicillium spores mailed to him from a pal at Wellcome Labs in London - and as spores do  - they traveled perfectly well indeed and started into making penicillin right away.

He was, like a rural Nova Scotian mom, making homemade penicillin in front of the patients to be consumed on the spot - and so like mom, didn't really need a whole lot of fancy high tech chemistry to render his penicillin safe.

His patients were wounded soldiers in his large base hospital and the liquid penicillin was barely produced by the penicillium spores in the hospital lab than it was coursing through the veins of the grateful soldiers : drying and chemical preservatives hardly entered into this cosy setup.

And he freely began to teach the local natives and other military units how to make their own penicillin with spores of his.

His efforts made Florey and Whitehall very angry indeed --- Britain hoped, once it had synthesized penicillin , to see a huge trade in penicillin in exchange for Egyptian cotton etc.

Nancy Atkinson because she was located in Adelaide Australia, Florey's home town, had his number and knew of his peculiar - grasping - personality.

 She avoided approaching Florey, got her penicillin from Fleming himself and soon got a local Adelaide firm to make local penicillin and gave some spores to Duhig in Brisbane so he too could goose up the tardy government approach to providing enough penicillin for civilian as well as soldier.

Florey was very angry that he - as the long time away "local boy" -  hadn't been invited in to help in Australia. Maybe his selfish and secretive attitude had something to do with it ?

I have said that the biggest reason for the long delay in providing wartime penicillin to those dying for lack of it was Florey, Flemings and AN Richards' obsession with weaponizing it.

By this I meant they rejected Pulvertaft and Duhig's implicit argument that penicillin was best used systemically (injected into the entire body) for life-threatening blood poisoning because - technically, as a drug - that is where it worked best.

 And that this being the case, life-threatening blood poisoning cases were almost always sent to the big hospitals with a big enough lab and staff  to make the penicillin,on the spot, for the steady stream of blood poisoning cases coming in.

There was no need to waste time making penicillin a stable enough material to send from a central factory to store in regional warehouses until traveling detail salesmen had sold it in small amounts to individual GPs.

Disagreeing strenuously,  Florey, Fleming, Richards et al felt the greatest war need was for a local antiseptic to be poured or sprinkled inside wounds on the battlefield , soon as a soldier was wounded.

Let me say that more careful research,after the war,( including some by Pulvertaft himself) concluded this was an artificial problem - and that into this square artificial hole both the round sulfa and round wartime penicillin were reluctantly pushed - both failing , but for different reasons.

But sulfa and penicillin did save many lives, but not on the battlefield, but rather back in the base hospital, doing what they did best - reach into every part of the body and killing bacteria out in the open.

Killing bacteria in hard to get to places remained (and remains) hard to do - but if these bacteria did not get into the blood stream, they were almost never fatal in and of themselves.

Weaponized penicillin was imperialized penicillin


But let us now combine weaponized penicillin with imperialized penicillin : because a dry , stable, complicatedly mass produced penicillin also suited the post war aims of Britain : to profitably sell high tech medicine to nations less advanced than European ones.

Convincing the lesser breeds that homemade (really made by skilled microbiologists in big hospital labs) penicillin, like homemade bread, was so un-civilizied , was at least half the battle.....

Tuesday, February 19, 2013

Resetting the Allied moral compass so that it diverged from the Nazis, not merely followed a muted parallel course

It remains unknown whether Henry Dawson expected his quixotic wartime efforts (to "waste" weaponized penicillin on 'useless' SBEs ) to go as far as they ultimately did.

He certainly was extremely unhappy that America was treating its wartime 'SBE lives unworthy of life' in almost as bad a fashion as Nazi Germany was known to be doing to its SBEs and others seen as "useless mouths".

But did he suspect his assault on weaponizing penicillin would extend beyond the Allies' horrific wartime neglect of the poorer chronically ill ?

He probably couldn't have foreseen just how quickly the pipeline of ever-newer ever-better sulfa drugs would dry up or just how quickly so many strains of deadly bacteria would become resistant to any sulfa drug , leaving penicillin as the  only  wartime lifesaver between disease and death.

This meant de-weaponizing penicillin had consequences far beyond those people suffering from SBE and denied their only chance at life.

If weaponized penicillin had remained throughout the war successfully censored and had remained denied to the civilian world (as weaponized DDT successfully was, never let us forget) , it would have ranked as one of WWII's major war crimes, like Katyn Forest or Auschwitz.

Millions of people around the world during WWII would have died needlessly from massive infections that only penicillin alone could have stopped.

Penicillin in 1943 was not as it is today,  just one among dozens of antibiotics - it was the only one - and in addition, no new anti-bacterial sulfa drugs were coming along to replace the ones that bacteria had so rapidly grown resistant to.

Refusing to divert a tiny amount of war resources to make penicillin available to civilians - anywhere and everywhere - was to refuse them Life itself.

Worse, there was no trade-off  to debate ; penicillin, like sulfa before it, was no war-winning secret medical weapon, at least in its intended war-winning use at the front .

Brand new (front line) wounds either contain abundant alternative bacteria foods to the deadly sulfa 'food' (the Fildes theory, known since 1940) or contain abundant proteins to bind to penicillin and render it useless.

However penicillin, and sulfa, were very useful a little further back in the military hospital system, as a life-saving systemic in cases of possible blood poisoning.

The case against secret weaponized penicillin gets even worse.

As an impure natural drug, penicillin would have taken the Germans at least a year or two or three to successfully mass produce it , even if its virtues had been sung from the heavens by the American media in 1942.

But as a pure synthetic penicillin in supposedly cheap abundant mass production (an event that in fact as not yet ever occurred) the chemistry-minded Germans would have rapidly back-engineered the drug and synthesized it rapidly themselves.

Because remember it took 15 years of hard effort to purify natural penicillin enough to determine its structure - but only months thereafter to 'synthesize' it artificially.

Back-engineering that synthesis would also only have taken months.

Penicillin's real secret was just how difficult the mass production of natural penicillin could be if you set your mind on doing everything the hard way ---- not the OSRD-Merck-Oxford fantasy of secret synthesis.

Dawson certainly set up the stage for the Allies re-setting of their moral compass , from his endocarditis efforts from September 1940 to September 1943 : but it was the immediate outcry resulting from the Patty Malone and Marie Barker cases that forced them to actually do something concrete.

His gut instinct in 1940 ,that not treating the otherwise fatal subacute bacterial endocarditis would prove the acid test for the Allies' pernicious morality, certainly was correct.

But while he couldn't have foreseen how far his actions would impact, he wouldn't have been unhappy that they did so......